Any guitarist can play the GR-300, using all standard guitar playing techniques, including: hammering, glissandos, harmonics, chopping, etc. The GR-300 produces effects and nuances which keyboard synthesizers cannot easily produce. In order to use the GR-300 Guitar Synthesizer unit you must have a Roland compatible guitar controller such as the G-303 or G-808 with the divided HEX pickup installed. To produce the effect of the GR-300, you would need: 6-octave shifters + 6-com pressor